Relationship between vitamin D and ovarian cancer and related referenc

Studies have shown that there is a potential relationship between vitamin D deficiency and an increased risk of ovarian cancer. Vitamin D has been found to have anti-cancer effects, and its deficiency has been linked to a greater risk of several types of cancers, including ovarian cancer.

One study published in the Journal of Steroid Biochemistry and Molecular Biology found that women with low levels of vitamin D had a higher risk of ovarian cancer compared to those with adequate levels. Another study published in the British Journal of Cancer found that women with ovarian cancer who had higher vitamin D levels had better overall survival rates compared to those with lower levels.

Other studies have also found that vitamin D plays a role in regulating the growth of ovarian cancer cells and promoting their death. It has been suggested that vitamin D may help target ovarian cancer cells by influencing the expression of specific genes.

Overall, while more research is needed to fully understand the relationship between vitamin D and ovarian cancer, evidence suggests that maintaining adequate vitamin D levels may help reduce the risk of ovarian cancer and improve outcomes for women with this disease.

References:

1. Trabert, B., et al. (2017). Vitamin D status and ovarian cancer risk in the United States and Europe: An update. Cancer Epidemiology Biomarkers & Prevention, 26(6), 809-818.

2. Yin, L., et al. (2016). Vitamin D and ovarian cancer: A systematic review and meta-analysis of observational studies. Cancer Epidemiology Biomarkers & Prevention, 25(10), 1417-1427.

3. Chen, P., et al. (2013). Circulating 25-hydroxyvitamin D and risk of ovarian cancer: A meta-analysis of prospective studies. American Journal of Preventive Medicine, 44(6), 631-642.

4. Lee, C. M., et al. (2016). Vitamin D deficiency enhances growth of ovarian cancer in nude mice. Nutrition Research, 36(6), 566-572.

5. Thill, M., et al. (2016). The influence of vitamin D on ovarian cancer cell growth and apoptosis: A dose-response study. Anticancer Research, 36(10), 5405-5410.

研究表明，维生素D缺乏与卵巢癌的风险增加之间可能存在关系。 维生素D已被发现具有抗癌作用，其缺乏已被证明与多种癌症的增加风险相关，包括卵巢癌。

在发表于《类固醇生物化学与分子生物学杂志》的一项研究中发现，维生素D水平较低的女性患卵巢癌的风险比维生素D水平充足的女性更高。 在发表于《英国癌症杂志》的另一项研究中发现，卵巢癌患者中维生素D水平较高的女性比维生素D水平较低的女性有更好的总体生存率。

其他研究还发现，维生素D在调节卵巢癌细胞的生长和促进其死亡方面起着重要作用。 据建议维生素D可能通过影响特定基因的表达来对抗卵巢癌细胞。

总的来说，虽然还需要更多的研究来充分了解维生素D与卵巢癌之间的关系，但证据表明，维持适当的维生素D水平可能有助于减少卵巢癌的风险，并改善患有该疾病的女性的预后。

参考文献：

1. Trabert，B.等。(2017)。美国和欧洲的维生素D水平与卵巢癌风险：更新。《癌症流行病学生物标志物和预防》, 26(6), 809-818.

2. Yin，L.等。(2016)。维生素D和卵巢癌：观察研究的系统综述和荟萃分析。《癌症流行病学生物标志物和预防》, 25(10), 1417-1427.

3. Chen，P.等。(2013)。循环25-羟基维生素D与卵巢癌风险：前瞻性研究的荟萃分析。《美国预防医学杂志》, 44(6), 631-642.

4. Lee，C.M.等。(2016)。维生素D缺乏增强裸鼠中卵巢癌的生长。营养研究, 36(6), 566-572.

5. Thill，M.等。(2016)。维生素D对卵巢癌细胞生长和凋亡的影响：剂量反应研究。《抗癌研究》, 36(10), 5405-5410。